Childhood maltreatment is a strong transdiagnostic risk factor for depression and anxiety disorders. This risk is driven, at least in part, because of stress hormone-mediated atrophy in the hippocampus, which leaves this area sensitive to further volume loss in adulthood when exposed to future stress and psychopathology. In a sample of 80 adults followed for 6 months, we found that those with higher symptoms of anxious arousal across the follow-up period experienced decreases in hippocampal volume over time, but only if they also had greater severity of childhood maltreatment. These novel results suggest that for individuals with a history of maltreatment, transdiagnostic interventions that target and reduce psychological and physiological arousal may result in the preservation of hippocampal structure and, thus, improvements in cognitive and emotional regulation in the face of stress.
Rowe et al. (2023). Journal of Psychopathology and Clinical Science. (Special Section)